… achieve this activation in cancer cells selectively is not clear. In this study, we show that
the drug-resistant 293 cell line is unable to activate components of the apoptotic machinery--the …

… inhibition in these oncogene-dependent tumors have not been … and crushed for protein
extraction in lysis buffer supplemented … cells were insensitive to erlotinib due to the drug-resistant …

… We noted difficulty in establishing cultures of drug-resistant cells … To confirm that resistant
cells remained oncogene dependent… DNA from tumour tissue was extracted using the DNeasy …

… To test this possibility, we examined T cell activation in both sensitive and drug-resistant
cells. We isolated T cells from OT-1 mice (containing a transgenic T cell receptor that recognizes …

… leading to the emergence of drug-resistant malignancies. Thus … oncogene-dependent changes
within the cancer cell that … in normal cytosolic extracts triggers nuclear apoptosis in a cell-…

… of drug-sensitive and drug-resistant tumor cells in a conditional … model of oncogene-dependent
cancer dynamics … recurring tumors and extracted genomic DNA with a DNA extraction kit (…

… To investigate this possibility, protein extracts of Jurkat T cells … the process of oncogene-dependent
apoptosis.Since caspase… to treating human cancers, including drug resistant tumors. …

… in apoptotic cell death. Activated oncogenes feed into both the cell-cycle and the apoptotic
… , implying the existence of a ‘multi-drug resistant’ phenotype; this is in accordance with the ‘…

… apoptosis than either K562 or its parental CEM cells. The sensitivity of leukemic cells to UV
light–induced apoptosis … S-100 was extracted from cells after exposure to UV light for 3 hours. …

… activity is seen in extracts of cells expressing E1A and the … to explain why oncogene-dependent
cell death can often be … Akt, or by expression of anti-apoptotic bcl-2 family members, both …